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Article

Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Aug 2023

Berke Gergő, Beer Sebastian, Gede Noémi, Takáts Amanda, Szentesi Andrea, Hegyi Péter, Rosendahl Jonas, Sahin-Tóth Miklós, Németh Balázs Csaba, Hegyi Eszter

Abstract excerpt

Chymotrypsin C (CTRC) is a digestive serine protease produced by the pancreas that regulates intrapancreatic trypsin activity and provides a defensive mechanism against chronic pancreatitis (CP). CTRC exerts its protective effect by promoting degradation of trypsinogen, the precursor to trypsin. Loss-of-function missense and microdeletion variants of CTRC are found in around 4% of CP cases and increase disease...

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Identifiers

PMID: 37321941
DOI: 10.1016/j.pan.2023.05.013
PMCID: PMC10586708

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Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.PMID 37321941Read ↗

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