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Article

Interleukin-6 Stromal Expression is Correlated with Epithelial-Mesenchymal Transition at Tumor Budding in Colorectal Cancer.

International journal of surgical pathology - 1 Apr 2024

Uehara Takeshi, Sato Koichi, Iwaya Mai, Asaka Shiho, Nakajima Tomoyuki, Nagaya Tadanobu, Kitazawa Masato, Ota Hiroyoshi

Abstract excerpt

Background. Tumor budding is a poor prognostic factor in colorectal adenocarcinoma, but the underlying mechanism remains unclear. Interleukin-6 (IL6) is one of the main cytokines produced by cancer-associated fibroblasts. IL6 is linked with cancer progression and poor prognosis by activating cancer cells and modifying the cancer microenvironment. However, little is known about the expression of IL6 in tumor...

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Identifiers

PMID: 37306249
DOI: 10.1177/10668969231177705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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