Article
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil.
BioMed research international - 1 Jan 2022
de Sá Nathalia Beatriz Ramos, Neira-Goulart Milena, Ribeiro-Alves Marcelo, Perazzo Hugo, Geraldo Kim Mattos, Ribeiro Maria Pia Diniz, Cardoso Sandra Wagner, Grinsztejn Beatriz, Veloso Valdiléa G, Capão Artur, Siqueira Marilda Mendonça, de Lima Bezerra Ohanna Cavalcanti, Garcia Cristiana Couto, Gomes Larissa Rodrigues, da Silva Cazote Andressa, de Almeida Dalziza Victalina, Giacoia-Gripp Carmem Beatriz Wagner, Côrtes Fernanda Heloise, Morgado Mariza Gonçalves
Abstract excerpt
COVID-19 has a broad spectrum of clinical manifestations, from asymptomatic or mild/moderate symptoms to severe symptoms and death. The mechanisms underlying its clinical evolution are still unclear. Upon SARS-CoV-2 infection, host factors, such as the inflammasome system, are activated by the presence of the virus inside host cells. The search for COVID-19 risk factors is of relevance for clinical management. In...
Topics
- Apoptosis Regulatory Proteins
- Brazil
- CARD Signaling Adaptor Proteins
- COVID-19
- Genetic Predisposition to Disease
- Humans
- Inflammasomes