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Article

Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin.

Nature - 1 Jun 2023

Griffin Gabriel K, Booth Christopher A G, Togami Katsuhiro, Chung Sun Sook, Ssozi Daniel, Verga Julia A, Bouyssou Juliette M, Lee Yoke Seng, Shanmugam Vignesh, Hornick Jason L, LeBoeuf Nicole R, Morgan Elizabeth A, Bernstein Bradley E, Hovestadt Volker, van Galen Peter, Lane Andrew A

Abstract excerpt

Tumours most often arise from progression of precursor clones within a single anatomical niche. In the bone marrow, clonal progenitors can undergo malignant transformation to acute leukaemia, or differentiate into immune cells that contribute to disease pathology in peripheral tissues1-4. Outside the marrow, these clones are potentially exposed to a variety of tissue-specific mutational processes, although the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37286599
DOI: 10.1038/s41586-023-06156-8
PMCID: PMC10284703

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