Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival.

Blood advances - 11 Jun 2024

Shimony Shai, Keating Julia, Fay Christopher J, Luskin Marlise R, Neuberg Donna S, LeBoeuf Nicole R, Lane Andrew A

Abstract excerpt

ABSTRACT: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) can involve skin, bone marrow (BM), central nervous system (CNS), and non-CNS extramedullary sites. Preclinical models demonstrated clonal advantage of TET2-mutated plasmacytoid dendritic cells exposed to UV radiation. However, whether sun exposure, disease characteristics, and patient survival are clinically related is unclear. We classified organ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Dioxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Hematologic Neoplasms

Share to Neoplasms

Share to Proto-Oncogene Proteins

Share to ras Proteins

Share to Sunlight

Source

Open in PubMed Open full text

Identifiers

PMID: 38603567
DOI: 10.1182/bloodadvances.2024012797
PMCID: PMC11176947

Genes

TET2
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival.PMID 38603567Read ↗

Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin.Semantic proximity Read ↗

Blastic Plasmacytoid Dendritic Cell Neoplasm: Updates in Diagnostic and Molecular Pathology.Semantic proximity Read ↗

Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow.Semantic proximity Read ↗

Integrative molecular profiling identifies two molecularly and clinically distinct subtypes of blastic plasmacytoid dendritic cell neoplasmSemantic proximity Read ↗

Profiling endogenous, environmental, and infectious disease mutational signatures in blastic plasmacytoid dendritic cell neoplasms.Semantic proximity Read ↗

The Clinicopathologic and Genomic Features of Mature Versus Blastic Plasmacytoid Dendritic Cell Neoplasms Arising From Chronic Myeloid Neoplasms.Semantic proximity Read ↗

Blastic plasmacytoid dendritic cell neoplasm with genetic mutations in multiple epigenetic modifiers: a case report.Semantic proximity Read ↗

Blastic Plasmacytoid Dendritic Cell Neoplasm With De Novo TET2 and KDM6A Mutations.Semantic proximity Read ↗

Cutaneous blastic plasmacytoid dendritic cell neoplasm arising in the context of TET2 and ZRSR2 mutated clonal cytopenias of unknown significance, secondary to somatic copy number losses involving CDK2NA/2NB and MTAP.Semantic proximity Read ↗

Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm.Semantic proximity Read ↗

Merkel Cell Carcinoma With Extensive Bone Marrow Metastasis and Peripheral Blood Involvement: A Case Report With Immunohistochemical and Mutational Studies.Semantic proximity Read ↗

Epidemiology and aetiology of basal cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.