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Article

Mitochondrial (dys)function – a factor underlying the variability of efavirenz‐induced hepatotoxicity?

20 Nov 2014

Abstract excerpt

BACKGROUND AND PURPOSE: The non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence has pinpointed a specific mitochondrial action of efavirenz accompanied by the induction of an endoplasmic reticulum (ER) stress/unfolded protein response in human hepatic cells. The aim of this...

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PMID: 25411110
DOI: 10.1111/bph.13018

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