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Mitotoxic effects of the melanin-concentrating hormone receptor 1 (MCHr1) antagonist AZD1979 are influenced by mitochondrial DNA variation in HepG2 cybrids.

Toxicology - 1 Feb 2026

Jensen Rebecca L, Kiy Robyn T, Jolly Carol E, Williams Dominic P, Chadwick Amy E

Abstract excerpt

AZD1979 is a melanin-concentrating hormone receptor 1 (MCHr1) antagonist, which was developed for obesity treatment, but clinical development was halted due to unanticipated liver toxicity. Mitochondrial DNA (mtDNA) variation influences hepatic energy metabolism and may underlie individual susceptibility to drug-induced mitotoxicity. Transmitochondrial cybrids offer a model to assess the impact of mtDNA variation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41349886
DOI: 10.1016/j.tox.2025.154365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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