Article
The genetics of testosterone contributes to "femaleness/maleness" of cardiometabolic traits and type 2 diabetes.
International journal of obesity (2005) - 1 Jan 2022
Vosberg Daniel E, Parker Nadine, Shin Jean, Pausova Zdenka, Paus Tomáš
Abstract excerpt
The genetic architecture of testosterone is highly distinct between sexes. Moreover, obesity is associated with higher testosterone in females but lower testosterone in males. Here, we ask whether male-specific testosterone variants are associated with a male pattern of obesity and type 2 diabetes (T2D) in females, and vice versa. In the UK Biobank, we conducted sex-specific genome-wide association studies and...
Topics
- Adult
- Diabetes Mellitus, Type 2
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Metabolic Syndrome
- Middle Aged
- Sex Differentiation
- Testosterone