Article
An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype.
American journal of respiratory and critical care medicine - 15 Jan 2013
Holguin Fernando, Comhair Suzy A A, Hazen Stanley L, Powers Robert W, Khatri Sumita S, Bleecker Eugene R, Busse William W, Calhoun William J, Castro Mario, Fitzpatrick Anne M, Gaston Benjamin, Israel Elliot, Jarjour Nizar N, Moore Wendy C, Peters Stephen P, Teague W Gerald, Chung Kian Fan, Erzurum Serpil C, Wenzel Sally E
Abstract excerpt
RATIONALE: Increasing body mass index (BMI) has been associated with less fractional exhaled nitric oxide (Fe(NO)). This may be explained by an increase in the concentration of asymmetric dimethyl arginine (ADMA) relative to L-arginine, which can lead to greater nitric oxide synthase uncoupling. OBJECTIVES: To compare this mechanism across age of asthma onset groups and determine its association with asthma...
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