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Article

Neurogenetic disorders associated with mutations in the FERRY complex: a novel disease class?

10 Mar 2025

Abstract excerpt

The five-subunit endosomal Rab5 and RNA/ribose intermediary (FERRY) complex is a newly described protein complex consisting of TBCK, PPP1R21, FERRY3 (previously C12orf4), CRYZL1, and GATD1. The FERRY complex is proposed to function as a Rab5 effector to shuttle mRNA to the cell periphery for local translation, a process especially important in cells with far reaching processes. Interestingly, three members of the...

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PMID: 40062705
DOI: 10.1242/bio.061808

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