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HIV-1 capsid stability enables inositol phosphate-independent infection of target cells and promotes integration into genes

2 Jun 2023

Abstract excerpt

The mature HIV-1 capsid is stabilized by host and viral determinants. The capsid protein CA binds to the cellular metabolites inositol hexakisphosphate (IP6) and its precursor inositol (1, 3, 4, 5, 6) pentakisphosphate (IP5) to stabilize the mature capsid. In target cells, capsid destabilization by the antiviral compounds lenacapavir and PF74 reveals a HIV-1 infectivity defect due to IP5/IP6 (IP5/6) depletion. To...

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PMID: 37267431
DOI: 10.1371/journal.ppat.1011423

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