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Article

Derivation and characterization of an HIV-1 mutant that rescues IP6 binding deficiency.

Retrovirology - 28 Aug 2021

Poston Daniel, Zang Trinity, Bieniasz Paul

Abstract excerpt

BACKGROUND: A critical step in the HIV-1 replication cycle is the assembly of Gag proteins to form virions at the plasma membrane. Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP6), which is proposed to stabilize both the immature Gag lattice and the mature capsid lattice by binding to rings of primary amines at the center of Gag or capsid protein (CA) hexamers....

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Share to Amino Acid Substitution
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Share to gag Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 34454514
DOI: 10.1186/s12977-021-00571-3
PMCID: PMC8403458

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