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Article

A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.

Viruses - 17 Sept 2021

Obr Martin, Schur Florian K M, Dick Robert A

Abstract excerpt

The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles. However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding site in the immature Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice via a second...

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Identifiers

PMID: 34578434
DOI: 10.3390/v13091853
PMCID: PMC8473085

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