Article
The Effect of Inositol Hexakisphosphate on HIV-1 Particle Production and Infectivity can be Modulated by Mutations that Affect the Stability of the Immature Gag Lattice.
Journal of molecular biology - 1 Jun 2023
Kleinpeter Alex B, Zhu Yanan, Mallery Donna L, Ablan Sherimay D, Chen Long, Hardenbrook Nathan, Saiardi Adolfo, James Leo C, Zhang Peijun, Freed Eric O
Abstract excerpt
The assembly of an HIV-1 particle begins with the construction of a spherical lattice composed of hexamer subunits of the Gag polyprotein. The cellular metabolite inositol hexakisphosphate (IP6) binds and stabilizes the immature Gag lattice via an interaction with the six-helix bundle (6HB), a crucial structural feature of Gag hexamers that modulates both virus assembly and infectivity. The 6HB must be stable...
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