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Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells

21 Jan 2021

Abstract excerpt

Gag polymerization with viral RNA at the plasma membrane initiates HIV-1 assembly. Assembly processes are inefficient in vitro but are stimulated by inositol (1,3,4,5,6) pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) metabolites. Previous studies have shown that depletion of these inositol phosphate species from HEK293T cells reduced HIV-1 particle production but did not alter the infectivity of the...

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PMID: 33476323
DOI: 10.1371/journal.ppat.1009190

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