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Article

The hallmarks of aging in Ataxia-Telangiectasia

26 May 2022

Abstract excerpt

Ataxia-telangiectasia (A-T) is caused by absence of the catalytic activity of ATM, a protein kinase that plays a central role in the DNA damage response, many branches of cellular metabolism, redox and mitochondrial homeostasis, and cell cycle regulation. A-T is a complex disorder characterized mainly by progressive cerebellar degeneration, immunodeficiency, radiation sensitivity, genome instability, and...

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PMID: 35644374
DOI: 10.1016/j.arr.2022.101653

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