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NAD + supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy

18 Mar 2021

Abstract excerpt

Abstract Senescence phenotypes and mitochondrial dysfunction are implicated in aging and in premature aging diseases, including ataxia telangiectasia (A‐T). Loss of mitochondrial function can drive age‐related decline in the brain, but little is known about whether improving mitochondrial homeostasis alleviates senescence phenotypes. We demonstrate here that mitochondrial dysfunction and cellular senescence with...

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PMID: 33734555
DOI: 10.1111/acel.13329

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