Article
The evolutionarily stable distribution of fitness effects.
Genetics - 1 May 2015
Rice Daniel P, Good Benjamin H, Desai Michael M
Abstract excerpt
The distribution of fitness effects (DFE) of new mutations is a key parameter in determining the course of evolution. This fact has motivated extensive efforts to measure the DFE or to predict it from first principles. However, just as the DFE determines the course of evolution, the evolutionary process itself constrains the DFE. Here, we analyze a simple model of genome evolution in a constant environment in...
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