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Article

A Model for Personalized in Vivo Analysis of Human Immune Responsiveness

14 Mar 2012

Abstract excerpt

Studies of human immune diseases are generally limited to the analysis of peripheral blood lymphocytes of heterogeneous patient populations. Improved models are needed to allow analysis of fundamental immunologic abnormalities predisposing to disease and in which to assess immunotherapies. Immunodeficient mice receiving human fetal thymus grafts and fetal CD34(+) cells intravenously produce robust human immune...

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PMID: 22422991
DOI: 10.1126/scitranslmed.3003481

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