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Hypermetabolism in mice carrying a near-complete human chromosome 21

9 May 2023

Abstract excerpt

The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcMAC21) carrying a near-complete human chromosome 21. Independent of diets and housing temperatures, TcMAC21 mice...

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PMID: 37249575
DOI: 10.7554/elife.86023

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