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Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers

27 May 2023

Abstract excerpt

BACKGROUND: Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genomic drivers in OSCC, but much remains to be elucidated about DNA methylation patterns across different stages of oral carcinogenesis. RESULTS: There is a serious lack of biomarkers and clinical...

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PMID: 37245006
DOI: 10.1186/s13148-023-01510-z

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