Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer

21 Apr 2017

Abstract excerpt

We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profiles of leukoplakia resemble those observed in later stages of OSCC and that several changes are associated with this progression, including amplification of 8q24.3,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Oral and gingival health research
Share to Tumors and Oncological Cases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28433800
DOI: 10.1016/j.tranon.2017.03.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal CancerPMID 28433800Read ↗

Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancersSemantic proximity Read ↗

Genomic Profiling of Advanced-Stage Oral Cancers Reveals Chromosome 11q Alterations as Markers of Poor Clinical OutcomeSemantic proximity Read ↗

Integrative analysis of genomic and transcriptomic data of normal, tumour, and co-occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour initiation and progression.Semantic proximity Read ↗

Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?Semantic proximity Read ↗

Transcriptomic analysis predicts the risk of progression of premalignant lesions in human tongueSemantic proximity Read ↗

Genome‐wide expression and copy number analysis identifies driver genes in gingivobuccal cancersSemantic proximity Read ↗

Lymph node metastasis in oral cancer is strongly associated with chromosomal instability and DNA repair defectsSemantic proximity Read ↗

Cytogenetic alterations and their molecular genetic correlates in head and neck squamous cell carcinoma: A next generation window to the biology of diseaseSemantic proximity Read ↗

Gingivobuccal Squamous Cell Carcinoma: A Different Genomic Entity.Semantic proximity Read ↗

Copy Number Alterations Predict Development of OSCC from Oral LeukoplakiaSemantic proximity Read ↗

Genetic alterations and clinical dimensions of oral cancer: a review.Semantic proximity Read ↗

Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell CarcinomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.