New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development.

doi:10.1158/1940-6207.CAPR-14-0179

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development.

Cancer prevention research (Philadelphia, Pa.) - 1 Nov 2015

Foy Jean-Philippe, Pickering Curtis R, Papadimitrakopoulou Vassiliki A, Jelinek Jaroslav, Lin Steven H, William William N, Frederick Mitchell J, Wang Jing, Lang Wenhua, Feng Lei, Zhang Li, Kim Edward S, Fan You H, Hong Waun K, El-Naggar Adel K, Lee J Jack, Myers Jeffrey N, Issa Jean-Pierre, Lippman Scott M, Mao Li, Saintigny Pierre

Abstract excerpt

DNA promoter methylation of tumor suppressor genes and global DNA hypomethylation are common features of head and neck cancers. Our goal was to identify early DNA methylation changes in oral premalignant lesions (OPL) that may serve as predictive markers of developing oral squamous cell carcinoma (OSCC). Using high-throughput DNA methylation profiles of 24 OPLs, we found that the top 86 genes differentially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Precancerous Conditions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to CpG Islands

Share to Disease-Free Survival

Share to DNA Methylation

Share to Mouth Neoplasms

Share to Proportional Hazards Models

Share to Receptor, Angiotensin, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 26342026
DOI: 10.1158/1940-6207.CAPR-14-0179
PMCID: PMC4777304

Genes

AGTR1
FOXI2
PENK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development.PMID 26342026Read ↗

Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancersSemantic proximity Read ↗

High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genesSemantic proximity Read ↗

CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panelSemantic proximity Read ↗

Transcriptional reprogramming in oral squamous carcinomaSemantic proximity Read ↗

Oral Cancer: Genetics and the Role of Precision Medicine.Semantic proximity Read ↗

Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survivalSemantic proximity Read ↗

Genome‐wide DNA methylation profiling in tongue squamous cell carcinomaSemantic proximity Read ↗

Long interspersed nuclear element 1 hypomethylation has novel prognostic value and potential utility in liquid biopsy for oral cavity cancerSemantic proximity Read ↗

Transcriptional expression profiles of oral squamous cell carcinomasSemantic proximity Read ↗

DNA methylation analysis by bisulfite next-generation sequencing for early detection of oral squamous cell carcinoma and high-grade squamous intraepithelial lesion from oral brushing.Semantic proximity Read ↗

Methylation of HPV 16 and EPB41L3 in oral gargles: Associations with oropharyngeal cancer detection and tumor characteristicsSemantic proximity Read ↗

Gene Expression Profiling Identifies Genes Predictive of Oral Squamous Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.