Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gingivobuccal Squamous Cell Carcinoma: A Different Genomic Entity.

Oral and maxillofacial surgery clinics of North America - 1 Aug 2026

Sambath Janani, Achyutha Snehitha, George Irene A, Prabhash Kumar, Limaye Sewanti, Kumar Prashant, Kuriakose Moni Abraham

Abstract excerpt

Gingivobuccal mucosal squamous cell carcinoma (GBMSCC) is a distinct head and neck cancer subtype strongly linked to areca nut and smokeless tobacco, often arising in a background of oral submucous fibrosis. Multiomics studies reveal recurrent mutations (TP53, FAT1, CASP8, PIK3CA, and AAM pathway genes), characteristic copy number alterations, and transcriptomic programs driven by extracellular matrix remodeling,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Areca
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Head and Neck Neoplasms

Share to Mouth Neoplasms

Share to Mutation

Share to Tobacco, Smokeless

Share to Tumor Microenvironment

Source

Identifiers

PMID: 41723026
DOI: 10.1016/j.coms.2025.12.003

Genes

CASP8
FAT1
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gingivobuccal Squamous Cell Carcinoma: A Different Genomic Entity.PMID 41723026Read ↗

Establishment and genomic characterization of gingivobuccal carcinoma cell lines with smokeless tobacco associated genetic alterations and oncogenic PIK3CA mutationSemantic proximity Read ↗

Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups.Semantic proximity Read ↗

Single‐cell transcriptomic analysis of gingivo‐buccal oral cancer reveals two dominant cellular programsSemantic proximity Read ↗

Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrenceSemantic proximity Read ↗

Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrenceSemantic proximity Read ↗

Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancerSemantic proximity Read ↗

Molecular landscape of head and neck cancer and implications for therapySemantic proximity Read ↗

Unravelling the heterogeneity of oral squamous cell carcinoma by integrative analysis of single‐cell and bulk transcriptome dataSemantic proximity Read ↗

Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.Semantic proximity Read ↗

Oral Squamous Cell Carcinoma: A Comprehensive Review of Risk Factors, Molecular Pathogenesis, and Prevention StrategiesSemantic proximity Read ↗

Comprehensive genomic characterization of head and neck squamous cell carcinomas.Semantic proximity Read ↗

The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.