Article
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
Nature genetics - 1 Dec 2016
Lesseur Corina, Diergaarde Brenda, Olshan Andrew F, Wünsch-Filho Victor, Ness Andrew R, Liu Geoffrey, Lacko Martin, Eluf-Neto José, Franceschi Silvia, Lagiou Pagona, Macfarlane Gary J, Richiardi Lorenzo, Boccia Stefania, Polesel Jerry, Kjaerheim Kristina, Zaridze David, Johansson Mattias, Menezes Ana M, Curado Maria Paula, Robinson Max, Ahrens Wolfgang, Canova Cristina, Znaor Ariana, Castellsagué Xavier, Conway David I, Holcátová Ivana, Mates Dana, Vilensky Marta, Healy Claire M, Szeszenia-Dąbrowska Neonila, Fabiánová Eleonóra, Lissowska Jolanta, Grandis Jennifer R, Weissler Mark C, Tajara Eloiza H, Nunes Fabio D, de Carvalho Marcos B, Thomas Steve, Hung Rayjean J, Peters Wilbert H M, Herrero Rolando, Cadoni Gabriella, Bueno-de-Mesquita H Bas, Steffen Annika, Agudo Antonio, Shangina Oxana, Xiao Xiangjun, Gaborieau Valérie, Chabrier Amélie, Anantharaman Devasena, Boffetta Paolo, Amos Christopher I, McKay James D, Brennan Paul
Abstract excerpt
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10-8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4...
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