Article
Endometrial Carcinomas With a Somatically Derived Yolk Sac Tumor Component Share Molecular Similarities to p53-abnormal Endometrial Carcinomas and Germ Cell Tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2026
Li Joshua J X, Chui M Herman, McCluggage W Glenn, Fadare Oluwole, Cheng Grace H W, Ko Jasmine M K, Dungog Cecile C, Lee Jacqueline H S, Ma Edmond S K, Tse Ka Yu, Ip Philip P C
Abstract excerpt
Primary endometrial carcinomas with somatically derived yolk sac tumor (YST) components are rare. We analyzed 23 such cases using detailed clinicopathologic, immunohistochemical, and molecular methods. The median patient age was 68 years. Elevated serum alpha-fetoprotein (AFP) was detected in 76.9% (10/13) of tested cases. International Federation of Gynecology and Obstetrics (FIGO) 2009 stages were I (n = 12,...
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