Article
"Surface epithelial slackening" pattern in endometrioid carcinoma: A morphological feature for differentiating the POLE mutation-subtype from the no specific molecular profile subtype.
Pathology, research and practice - 1 Jul 2023
Kitazono Ikumi, Akahane Toshiaki, Yokoyama Seiya, Kobayashi Yusuke, Togami Shinichi, Yanazume Shintaro, Tasaki Takashi, Noguchi Hirotsugu, Tabata Kazuhiro, Kobayashi Hiroaki, Tanimoto Akihide
Abstract excerpt
Endometrial cancers are classified into mismatch repair (MMR) deficient- (MMRd), p53 mutation- (p53mut), DNA polymerase epsilon (POLE) mutation (POLEmut), and no specific molecular profile (NSMP) subtypes according to The Cancer Genome Atlas (TCGA). The distinction between POLEmut and NSMP subtypes is made on the basis of molecular analysis because the specific histological and immunohistochemical features of...
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