Article
Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocytic leukemia revealed by quantitative expression analysis of cell cycle, activation, and apoptosis-associated genes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 2005
Kienle Dirk L, Korz Christian, Hosch Beate, Benner Axel, Mertens Daniel, Habermann Annett, Kröber Alexander, Jäger Ulrich, Lichter Peter, Döhner Hartmut, Stilgenbauer Stephan
Abstract excerpt
PURPOSE: In patients with chronic lymphocytic leukemia (CLL), the VH mutation status and genomic aberrations (13q-, +12q, 11q-, 17p-) identify distinct prognostic subgroups. The aim was to elucidate biologic mechanisms through which these genetic markers may exert their pathogenic influence. PATI...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.