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Article

Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways.

Haematologica - 1 Dec 2018

Abruzzo Lynne V, Herling Carmen D, Calin George A, Oakes Christopher, Barron Lynn L, Banks Haley E, Katju Vikram, Keating Michael J, Coombes Kevin R

Abstract excerpt

Although trisomy 12 (+12) chronic lymphocytic leukemia (CLL) comprises about 20% of cases, relatively little is known about its pathophysiology. These cases often demonstrate atypical morphological and immunophenotypic features, high proliferative rates, unmutated immunoglobulin heavy chain variable region genes, and a high frequency of NOTCH1 mutation. Patients with +12 CLL have an intermediate prognosis, and...

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Share to 5'-Nucleotidase
Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to GPI-Linked Proteins

Share to Immunoglobulin Variable Region

Share to NFATC Transcription Factors

Share to Receptor, Notch1

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Source

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Identifiers

PMID: 29976738
DOI: 10.3324/haematol.2018.190132
PMCID: PMC6269288

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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