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Female XX sex chromosomes increase survival and extend lifespan in aging mice

17 Dec 2018

Abstract excerpt

Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex-based differences in...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Sex and Gender in Healthcare

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PMID: 30560587
DOI: 10.1111/acel.12871

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