Article
Patterns of TDP-43 Deposition in Brains with LRRK2 G2019S Mutations.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2023
Agin-Liebes Julian, Hickman Richard A, Vonsattel Jean Paul, Faust Phyllis L, Flowers Xena, Utkina Sosunova Irina, Ntiri Joel, Mayeux Richard, Surface Matthew, Marder Karen, Fahn Stanley, Przedborski Serge, Alcalay Roy N
Abstract excerpt
OBJECTIVE: To assess for TDP-43 deposits in brains with and without a LRRK2 G2019S mutation. BACKGROUND: LRRK2 G2019S mutations have been associated with parkinsonism and a wide range of pathological findings. There are no systematic studies examining the frequency and extent of TDP-43 deposits in neuropathological samples from LRRK2 G2019S carriers. METHODS: Twelve brains with LRRK2 G2019S mutations were...
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