Reproducibility metrics for context-specific CRISPR screens.

Abstract excerpt

CRISPR screens are used extensively to systematically interrogate the phenotype-to-genotype problem. In contrast to early CRISPR screens, which defined core cell fitness genes, most current efforts now aim to identify context-specific phenotypes that differentiate a cell line, genetic background, or condition of interest, such as a drug treatment. While CRISPR-related technologies have shown great promise and a...

Topics

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• Cell Line
• Clustered Regularly Interspaced Short Palindromic Repeats
• Phenotype
• Reproducibility of Results