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Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification

17 Jun 2025

Abstract excerpt

BACKGROUND: The heterogeneity of bladder cancer (BLCA) is affected by its inherent transcriptional properties and tumor microenvironment (TME). Stromal transcriptional components in the TME significantly influence the transcriptional classification of BLCA, and the intrinsic biological transcriptional characteristics of cancer cells may be obscured by the dominant, lineage-dependent transcriptional components of...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 40528211
DOI: 10.1186/s12967-025-06682-1

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