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Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

11 Jan 2025

Abstract excerpt

The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2 evolution. This was associated with phenotypic changes including evasion of pre-existing immunity and decreased disease severity. Continuous evolution within the Omicron lineage raised concerns of potential increased transmissibility and/or disease severity. To address this, we evaluate the fitness and pathogenesis of...

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PMID: 39799119
DOI: 10.1038/s41467-025-55938-3

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