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Article

Metabolic profiling of frailty, associations with type 2 diabetes and interaction with genetic susceptibility.

Cardiovascular diabetology - 24 May 2025

Wang Yuxiang, Chen Shuang, Li Yue, Lu Qi, Li Rui, Chen Jun-Xiang, Zhang Ji-Juan, Yu Hancheng, Xu Hanrui, Xie Jinchi, Li Xianli, Liu Gang, Pan An, Geng Tingting, Liao Yun-Fei

Abstract excerpt

BACKGROUND: Individuals with frailty are at increased risk of type 2 diabetes (T2D), but the underlying mechanisms are unclear. We aimed to investigate whether the frailty-T2D association is mediated by alterations in the metabolome and assess potential interaction with genetic susceptibility to diabetes. METHODS: This retrospective analysis, using data from a large prospective population-based cohort, included a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40413504
DOI: 10.1186/s12933-025-02776-8
PMCID: PMC12102881

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