Article
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty.
Nature communications - 5 Nov 2019
Rattray Nicholas J W, Trivedi Drupad K, Xu Yun, Chandola Tarani, Johnson Caroline H, Marshall Alan D, Mekli Krisztina, Rattray Zahra, Tampubolon Gindo, Vanhoutte Bram, White Iain R, Wu Frederick C W, Pendleton Neil, Nazroo James, Goodacre Royston
Abstract excerpt
Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in poor health in later life. In this study, we present a population level assessment of the metabolic phenotype...
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