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The bio3 mutation in sake yeast leads to changes in organic acid profiles and ester levels but not ethanol production.

Journal of bioscience and bioengineering - 1 Jul 2023

Takase Shiori, Tomonaga Kazuko, Tanaka Jumpei, Moriya Chise, Kiyoshi Keiji, Akao Takeshi, Watanabe Kota, Kadokura Toshimori, Nakayama Shunichi

Abstract excerpt

Biotin is an essential coenzyme that is bound to carboxylases and participates in fatty acid synthesis. The fact that sake yeast exhibit biotin prototrophy while almost all other Saccharomyces cerevisiae strains exhibit biotin auxotrophy, implies that biotin prototrophy is an important factor in sake brewing. In this study, we inserted a stop codon into the biotin biosynthetic BIO3 gene (cording for...

Topics

Saccharomyces cerevisiae
Ethanol
Alcoholic Beverages
Saccharomyces cerevisiae Proteins
Esters
Biotin
Fermentation
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37183145
DOI: 10.1016/j.jbiosc.2023.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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