Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake.

Gene - 17 May 1999

Phalip V, Kuhn I, Lemoine Y, Jeltsch J M

Abstract excerpt

An engineered mutant of Saccharomyces cerevisiae affected in biotin biosynthesis has been isolated. This mutant allowed the characterization of a bio cluster (BIO3-4-5). We demonstrate that BIO3 (YNR058w) and BIO4 (YNR057c) encode, respectively, a 7, 8-diaminopelargonic acid aminotransferase and a dethiobiotin synthase, involved in the biotin biosynthesis pathway. A novel gene, BIO5 (YNR056c), is present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Biological Transport
Share to Biotin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carbon-Nitrogen Ligases

Share to DNA Transposable Elements

Share to Genes, Fungal

Share to Multigene Family

Share to Transaminases

Source

Identifiers

PMID: 10333520
DOI: 10.1016/s0378-1119(99)00117-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake.PMID 10333520Read ↗

Identification and characterization of a novel biotin biosynthesis gene in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant.Semantic proximity Read ↗

Laboratory Evolution of a Biotin-Requiring Saccharomyces cerevisiae Strain for Full Biotin Prototrophy and Identification of Causal Mutations.Semantic proximity Read ↗

A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis.Semantic proximity Read ↗

Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis.Semantic proximity Read ↗

Isolation and characterization of the plasma membrane biotin transporter from Schizosaccharomyces pombe.Semantic proximity Read ↗

The bio3 mutation in sake yeast leads to changes in organic acid profiles and ester levels but not ethanol production.Semantic proximity Read ↗

Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase.Semantic proximity Read ↗

Biotin deficiency causes spontaneous cell death and activation of defense signaling.Semantic proximity Read ↗

Biotin synthesis in higher plants: isolation of a cDNA encoding Arabidopsis thaliana bioB-gene product equivalent by functional complementation of a biotin auxotroph mutant bioB105 of Escherichia coli K12.Semantic proximity Read ↗

Contributions of the peroxisome and β-oxidation cycle to biotin synthesis in fungi.Semantic proximity Read ↗

The gene encoding the biotin-apoprotein ligase of Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.