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Genome Editing to Generate Sake Yeast Strains with Eight Mutations That Confer Excellent Brewing Characteristics.

Cells - 24 May 2021

Chadani Tomoya, Ohnuki Shinsuke, Isogai Atsuko, Goshima Tetsuya, Kashima Mao, Ghanegolmohammadi Farzan, Nishi Tomoyuki, Hirata Dai, Watanabe Daisuke, Kitamoto Katsuhiko, Akao Takeshi, Ohya Yoshikazu

Abstract excerpt

Sake yeast is mostly diploid, so the introduction of recessive mutations to improve brewing characteristics requires considerable effort. To construct sake yeast with multiple excellent brewing characteristics, we used an evidence-based approach that exploits genome editing technology. Our breeding targeted the AWA1, CAR1, MDE1, and FAS2 genes. We introduced eight mutations into standard sake yeast to construct a...

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PMID: 34073778
DOI: 10.3390/cells10061299
PMCID: PMC8225151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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