Article
Protective effects of the sickle cell gene against malaria morbidity and mortality.
Lancet (London, England) - 13 Apr 2002
Aidoo Michael, Terlouw Dianne J, Kolczak Margarette S, McElroy Peter D, ter Kuile Feiko O, Kariuki Simon, Nahlen Bernard L, Lal Altaf A, Udhayakumar Venkatachalam
Abstract excerpt
The high frequency of the sickle-cell haemoglobin (HbS) gene in malaria endemic regions is believed to be due to a heterozygote (HbAS) advantage against fatal malaria. Data to prospectively confirm the protection associated with HbAS against mortality are lacking. We show that HbAS provides significant protection against all-cause mortality, severe malarial anaemia, and high-density parasitaemia. This significant...
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