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Article

Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait.

Blood - 19 Apr 2012

Gong Lauren, Maiteki-Sebuguzi Catherine, Rosenthal Philip J, Hubbard Alan E, Drakeley Chris J, Dorsey Grant, Greenhouse Bryan

Abstract excerpt

Sickle cell trait (HbAS) is known to be protective against Plasmodium falciparum malaria, but it is unclear when during the course of infection this protection occurs and whether protection is innate or acquired. To address these questions, a cohort of 601 children 1-10 years of age were enrolled in Kampala, Uganda, and followed for 18 months for symptomatic malaria and asymptomatic parasitemia. Genotyping was...

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Identifiers

PMID: 22327223
DOI: 10.1182/blood-2011-08-371062
PMCID: PMC3335384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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