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Article

A vast evolutionarily transient translatome contributes to phenotype and fitness.

Cell systems - 17 May 2023

Wacholder Aaron, Parikh Saurin Bipin, Coelho Nelson Castilho, Acar Omer, Houghton Carly, Chou Lin, Carvunis Anne-Ruxandra

Abstract excerpt

Translation is the process by which ribosomes synthesize proteins. Ribosome profiling recently revealed that many short sequences previously thought to be noncoding are pervasively translated. To identify protein-coding genes in this noncanonical translatome, we combine an integrative framework for extremely sensitive ribosome profiling analysis, iRibo, with high-powered selection inferences tailored for short...

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Identifiers

PMID: 37164009
DOI: 10.1016/j.cels.2023.04.002
PMCID: PMC10348077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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