Article
Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy.
Science advances - 10 May 2023
Wong Ho Yi, Lee Ruby C, Chong Sharene, Kapadia Stuti, Freeman Michael, Murigneux Valentine, Brown Susan, Soyer H Peter, Roy Edwige, Khosrotehrani Kiarash
Abstract excerpt
The main carcinogen for keratinocyte skin cancers (KCs) such as basal and squamous cell carcinomas is ultraviolet (UV) radiation. There is growing evidence that accumulation of mutations and clonal expansion play a key role in KC development. The relationship between UV exposure, epidermal mutation load, and KCs remains unclear. Here, we examined the mutation load in both murine (n = 23) and human (n = 37)...
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