Article
Comparison of tumor-informed and tumor-naïve sequencing assays for ctDNA detection in breast cancer.
EMBO molecular medicine - 7 Jun 2023
Santonja Angela, Cooper Wendy N, Eldridge Matthew D, Edwards Paul A W, Morris James A, Edwards Abigail R, Zhao Hui, Heider Katrin, Couturier Dominique-Laurent, Vijayaraghavan Aadhitthya, Mennea Paulius, Ditter Emma-Jane, Smith Christopher G, Boursnell Chris, Manzano García Raquel, Rueda Oscar M, Beddowes Emma, Biggs Heather, Sammut Stephen-John, Rosenfeld Nitzan, Caldas Carlos, Abraham Jean E, Gale Davina
Abstract excerpt
Analysis of circulating tumor DNA (ctDNA) to monitor cancer dynamics and detect minimal residual disease has been an area of increasing interest. Multiple methods have been proposed but few studies have compared the performance of different approaches. Here, we compare detection of ctDNA in serial plasma samples from patients with breast cancer using different tumor-informed and tumor-naïve assays designed to...
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