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Targeting homologous recombination deficiency in uterine leiomyosarcoma

4 May 2023

Abstract excerpt

BACKGROUND: Uterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year survival of < 10%. Mutations in the homologous recombination (HR) DNA repair pathway have been observed in ~ 10% of uLMS cases, with reports of some individuals benefiting from poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) therapy, which targets this DNA...

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PMID: 37143137
DOI: 10.1186/s13046-023-02687-0

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