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Article

CDX2 Enhances HTR-8/SVneo Trophoblast Cell Invasion by Altering the Expression of Matrix Metalloproteinases

1 Jan 2014

Abstract excerpt

BACKGROUND/AIMS: The invasion of trophoblast cells into the maternal uterine decidua is critical for normal placentation, establishment of pregnancy and maintenance of fetal growth in humans. Several growth factors and cytokines have been implicated in trophoblast invasion, but the underlying regulatory mechanisms of invasion are not fully understood. Our earlier studies have found that caudal-related homeobox...

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Share to Pregnancy and preeclampsia studies
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Identifiers

PMID: 25171776
DOI: 10.1159/000363028

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Related research

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Research trail→

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CDX2 Enhances HTR-8/SVneo Trophoblast Cell Invasion by Altering the Expression of Matrix MetalloproteinasesPMID 25171776Read ↗

CDX1 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expressionSemantic proximity Read ↗

MSX2 Induces Trophoblast Invasion in Human PlacentaSemantic proximity Read ↗

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Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expressionSemantic proximity Read ↗

miR‐346 and miR‐582‐3p‐regulated EG‐VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9Semantic proximity Read ↗

The decreased lncRNA ZEB2‐AS1 in pre‐eclampsia controls the trophoblastic cell line HTR‐8/SVneo's invasive and migratory abilities via the miR‐149/PGF axisSemantic proximity Read ↗

EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expressionSemantic proximity Read ↗

CTHRC1 promotes growth, migration and invasion of trophoblasts via reciprocal Wnt/β-catenin regulationSemantic proximity Read ↗

Imbalance between matrix metalloproteinases and their tissue inhibitors in preeclampsia and gestational trophoblastic diseasesSemantic proximity Read ↗

Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signalingSemantic proximity Read ↗

Identification of Novel Trophoblast Invasion-Related Genes: Heme Oxygenase-1 Controls Motility via Peroxisome Proliferator-Activated Receptor γSemantic proximity Read ↗

Involvement of WNT2 in trophoblast cell behavior in preeclampsia developmentSemantic proximity Read ↗

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