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LncRNA MEG3 inhibits trophoblast invasion and trophoblast‐mediated VSMC loss in uterine spiral artery remodeling

8 May 2019

Abstract excerpt

Extravillous trophoblasts (EVTs) migrate into uterine decidua and induce vascular smooth muscle cell (VSMC) loss through mechanisms thought to involve migration and apoptosis, achieving complete spiral artery remodeling. Long noncoding RNA maternally expressed gene 3 (MEG3) can regulate diverse cellular processes, such as proliferation and migration, and has been discovered highly expressed in human placenta...

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PMID: 31066488
DOI: 10.1002/mrd.23147

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