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Article

EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression

7 Oct 2021

Abstract excerpt

BACKGROUND: During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant trophoblast cell invasion is associated with placental diseases. Epidermal growth factor (EGF) and its receptor, EGFR, are expressed in trophoblast cells. Although the pro-invasive effect of EGF on trophoblast cells has been reported, the underlying mechanism remains largely unknown. RESULTS: In the present study, we...

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Share to Gestational Trophoblastic Disease Studies
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PMID: 34620174
DOI: 10.1186/s12964-021-00783-2

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