Parkinson’s disease-associated iPLA2-VIA/ PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

Abstract excerpt

Significance The mechanisms of α-synuclein aggregation and subsequent Lewy body formation are a key pathogenesis of Parkinson’s disease (PD). PARK14 -linked PD, which is caused by mutations of the iPLA2-VIA/PLA2G6 gene, exhibits a marked Lewy body pathology. iPLA2-VIA , which belongs to the phospholipase A 2 family, is another causative gene of neurodegeneration with brain iron accumulation (NBIA). Here, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurological diseases and metabolism
• Share to Oral and gingival health research
• Share to Parkinson's Disease Mechanisms and Treatments