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Article

Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice.

Scientific reports - 18 Jun 2021

Chen Liuji, Na Ren, Danae McLane Kirsten, Thompson Cody Sylvester, Gao Ju, Wang Xinglong, Ran Qitao

Abstract excerpt

Degeneration and death of motor neurons in Amyotrophic Lateral Sclerosis (ALS) are associated with increased lipid peroxidation. Lipid peroxidation is the driver of ferroptosis, an iron-dependent oxidative mode of cell death. However, the importance of ferroptosis in motor neuron degeneration of ALS remains unclear. Glutathione peroxidase 4 (Gpx4) is a key enzyme in suppressing ferroptosis by reducing...

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Identifiers

PMID: 34145375
DOI: 10.1038/s41598-021-92369-8
PMCID: PMC8213805

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